Yes, hello there again dear good friend
Yes of course you can, as long you keep up your emulator up to date and keep updating the game apps - including Skullgirls - from the main Official Google play store/itself.
One more important thing is required that you should always keep up your Google Play account up to date. (everything as possible)
Please don't download Android game apps games from other sites other than Google Play official because they may contain hack mods which may result either your game to be corrupted or worst to be banned from account from the Devs.
I had experienced this many times under other RPG On Line games including Idke Heroes and LoL (League of Legends) and Mobile version and others.
I've been dealing with PC emulators for over 8 yrs already from Playstation 2 to PS3 and other game platforms